Zhang Research Group: Biomaterials and Nanomedicines

 

School of Chemical Engineering and Technology,

 

Key laboratory of Systems Bioengineering (MOE),

Tianjin University, Tianjin, P. R. China

 

 

Diagnose and Treat Life-threatening Diseases by NanoBiotechnology

 

NanoBiotechnology

 

Broadly, we are taking advantages of emerging nanobiotechnology to solve key medical problems. As an example, We use nanotechnolgy-based strategies to develop safer and more effective vaccine formulations. By making adjuvant and antigen co-delivery nanosystems, we aim to train the immune systems fighting againt a wide variety of diseases such as cancers and infectious diseases. In addition, we are greatly interested in CRISPR-Cas9 delivery. Please refer to

 

    Li et al, Coordination Chemistry Reviews, 2022, 455, 214345  (Metal-based nanovaccines) 

    Li et al Chemistry of Materials, 2021, 33, 24, 9780-9794  (Metal micelles for cancer immunotherapy)

    Ren et al, ACS Applied Materials & Interfaces, 2022, DOI: 10.1021/acsami.1c18117 (Immunotherapy)

    Zhang et al, Advanced Healthcare Materials, 2022, DOI: 10.1002/adhm.202102365  (CRISPR-Cas9 delivery)

 

 

Drug Delivery

 

Toxicity is a serious roadblocker in pharmaceutical research, preventing the vast majority of drug formulations going into clinics. Therefore, to solve the toxicity issue, we developed a series of polymeric drug delivery systems such as surfactant-stripped induced frozen micelles (ss-infroms) and crosslinked micelles. The primary goal is to develop safe and smart drug delivery systems for different biological environments. Our research interests involve delivery of small molecules, peptides and proteins. Please refer to 

 

    Zhang et al Nature Communications, (2016), 7, 11649 ,

    Zhang et al, Current Opinion in Biotechnology, (2018), 52, 25,

    Yang et al, Journal of Controlled Release, (2022) 341, 329-340

 

    Yang et al, ACS Applied Materials & Interfaces, (2021) 13, 8, 9630-9642

 

 

Molecular Imaging

 

Early detection and precisely monitoring disease conditions are greatly needed for disease diagnosis. Towards that end, we have developed a new method for the generation of a novel class of nanoplatform termed surfactant stripped induced frozen micelles (ss-infroms) that can be used for non-invasive imaging of intestine, tumor, lymph node, etc with high resolution and specificity. Ss-infroms can be concentrated to very high concentration (absorbance>1000), likely representing the most colorful materials, which is advantagous for bioimaging with high resolution and without penetration depth limitation. We are particularly interested in intestinal imaging. Please refer to 

 

    Zhang et al Nature Nanotechnology, (2014) 9, 631  

    Zhang et al Advanced Materials, (2016) 28, 8524

    Jiang et al Advanced Healthcare Materials, (2021), 10, 2100356

    Ding et al Small, 2021, DOI:10.1002/smll.202104132