Diagnose and Treat Life-threatening Diseases by NanoBiotechnology
Broadly, we are taking advantages of novel nanobiotechnology to solve key medical problems. As an example, vaccine nanotechnology is an emerging technology that makes use of immune response for disease treatments. We use nanoparticle-based strategies to develop safer and more effective vaccine formulations. By making adjuvant and antigen co-delivery nanosystems, we aim to train the immune systems fighting againt a wide variety of diseases such as cancers and infectious diseases.
Toxicity is a serious side effect in pharmaceutical research, preventing the vast majority of drug formulations going into clinics. Therefore, to solve the toxicity issue, we developed a series of polymeric drug delivery systems such as surfactant-stripped induced frozen micelles (ss-infroms) and crosslinked micelles. The primary goal is to develop safe and smart drug delivery systems for different biological environments. Our research interests involve delivery of small molecules (e.g. anticancer drugs, antibiotics), peptides and proteins (e.g. CRISPR-Cas 9). Please refer to Zhang et al Nature Communications, (2016), 7, 11649 and Zhang et al, Current Opinion in Biotechnology, (2018), 52, 25.
Early detection and precisely monitoring disease conditions are greatly needed for disease diagnosis. Towards that end, we have developed a new method for the generation of a novel class of nanoplatform termed surfactant stripped induced frozen micelles (ss-infroms) that can be used for non-invasive imaging of intestine, tumor, lymph node, etc with high resolution and specificity. Ss-infroms can be concentrated to very high concentration (absorbance>1000), likely representing the most colorful materials, which is advantagous for bioimaging with high resolution and without penetration depth limitation. We are particularly interested in intestinal imaging. Please refer to Zhang et al Nature Nanotechnology, (2014) 9, 631 and Zhang et al Advanced Materials, (2016) 28, 8524